Mitochondrial Longevity Study on Somniosus microcephalus

Goal: To identify genetic differences in mitochondrial ND6 protein between Greenland shark (400+ years lifespan) and velvet dogfish (70 years lifespan). Key Finding: 10 amino acid differences were identified between the two species. The most significant mutation found was "TK→AE" at positions 107-108 amino acids. Mutation Impact: • Charge reversal: +1 (Lysine) → -1 (Glutamic acid) • Loss of hydrogen bonding ability: Threonine → Alanine This study suggests potential mitochondrial mechanisms underlying extreme longevity in Greenland sharks, with implications for aging research.