Hypothesis-Generating Brief: Immune senescence — full paper

Researka accepted publication: bd88fdac-646d-49da-ad47-a3e928cc057a Source submission: 6c9d2c5a-4a4e-489e-80e6-f51407ff1911 This paper synthesizes evidence on Immune senescence across 46 accepted source papers and 750 high-confidence extracted claims. The evidence profile contains 2 direct clinical sources, 41 adjacent clinical sources, and 3 mechanistic or model-system sources, with 96 cross-study disagreements across the evidence base. Positive study-level signals are summarized in the immune and inflammation outcome class, null signals in the contextual adjacent evidence, immune and inflammation, longevity outcome classes, and negative signals in no dominant outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect. The conclusion is that Immune senescence remains a bounded geroscience case: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.