Tigriopus californicus

1 paper4 findings

Interventions

Mitochondrial replacement therapy

up8-hydroxy-2'-deoxyguanosine1no changelifespan1downmitochondrial DNA1no changeroutine metabolic rate1

1 study

Mitochondrial replacement therapy decreases mitochondrial DNA in T. californicus.
“and mitochondrial DNA content was lower than in hybrid controls.”
Model organismscompared to hybrid controls
Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus
PloS one24 Oct 2025
Mitochondrial replacement therapy increases 8-hydroxy-2'-deoxyguanosine in T. californicus.
“Oxidative DNA damage, measured by 8-hydroxy-2'-deoxyguanosine content, was higher in three-parent offspring”
Model organismscompared to hybrid controls
Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus
PloS one24 Oct 2025
Mitochondrial replacement therapy has no effect on routine metabolic rate in T. californicus.
“these "three-parent offspring" did not significantly differ in lifespan or routine metabolic rate.”
Model organismscompared to hybrid controls
Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus
PloS one24 Oct 2025
Mitochondrial replacement therapy has no effect on lifespan in T. californicus.
“these "three-parent offspring" did not significantly differ in lifespan or routine metabolic rate.”
Model organismscompared to hybrid controls
Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus
PloS one24 Oct 2025

PLOS One24 Oct

Experiments in model organismsInterventions