Mammalian cells

1. Rapamycin decreases mTOR antiviral activity in M. cells cells.

   “rapamycin strengthening FKBP12-mTOR association blocks mTOR antiviral activity by recruiting SIRT2 to deacetylate FKBP12.”

   Cells

   Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

   iScience·Sep 27, 2021

2. Rapamycin increases SIRT2 recruitment to FKBP12 in M. cells cells.

   “Rapamycin recruits SIRT2 with a high affinity for FKBP12 association and deacetylation.”

   Cells

   Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

   iScience·Sep 27, 2021

3. Rapamycin is associated with mitochondrial phosphoproteome in M. cells cells (mTOR inhibited with rapamycin) (dramatic alteration).

   “inhibiting mTOR with rapamycin resulted in a dramatic alteration in the mitochondrial phosphoproteome.”

   CellsmTOR inhibited with rapamycin

   The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

   The Journal of biological chemistry·Jul 17, 2006

4. Rapamycin decreases oxygen consumption in M. cells cells (rapamycin-treated cells with mTOR-raptor complex disrupted).

   “Disruption of this complex following treatment with the mTOR pharmacological inhibitor rapamycin lowered mitochondrial membrane potential, oxygen consumption, and ATP synthetic capacity.”

   Cellsrapamycin-treated cells with mTOR-raptor complex disrupted

   The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

   The Journal of biological chemistry·Jul 17, 2006

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1. Etasr induces Hpd disruption in vivo.

   “single-AAV delivery enabled efficient Hpd disruption in vivo”

   Animalsin vivosingle-AAV delivery

   Engineered tool improves DNA editing in mammalian cells

   bioRxiv·Nov 13, 2026Preprint

2. Etasr increases genome editing efficiency in M. cells cells (compared with original ParTasR) (4.29% to 48.94%; average 26.52-fold increase).

   “eTasR increased mammalian editing efficiency from the original 4.29% to 48.94% with an average 26.52-fold increase”

   Cellscompared with original ParTasRmammalian cells

   Engineered tool improves DNA editing in mammalian cells

   bioRxiv·Nov 13, 2026Preprint

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1. Thymidine improves A-product purity in mammalian cells with glycosylase-derived base editors (up to 2.7-fold).

   “improved A-product purity by up to 2.7-fold”

   Cellsin mammalian cells with glycosylase-derived base editors

   Harnessing nucleotide metabolism to control glycosylase base editing outcomes

   Theranostics·Feb 4, 2026

2. Thymidine increases base editing efficiency in mammalian cells with glycosylase-derived base editors (up to 4-fold).

   “increased C-to-A, G-to-A, and T-to-A editing efficiencies by up to 4-fold, 1.8-fold, and 1.8-fold, respectively”

   Cellsin mammalian cells with glycosylase-derived base editors

   Harnessing nucleotide metabolism to control glycosylase base editing outcomes

   Theranostics·Feb 4, 2026

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1. Nobiletin increases PER2 amplitude in M. cells (putative RORα/γ agonism).

   “increased period circadian regulator 2 (PER2) amplitude and period”

   Reviewputative RORα/γ agonismlow micromolar concentrations

   Effects of (Poly)phenols on Circadian Clock Gene-Mediated Metabolic Homeostasis in Cultured Mammalian Cells: A Scoping Review

   Advances in nutrition (Bethesda, Md.)·Apr 20, 2024

2. Nobiletin induces BMAL1 in M. cells (putative RORα/γ agonism).

   “leading to induction of the circadian regulator brain and muscle ARNT-like 1 (BMAL1)”

   Reviewputative RORα/γ agonismlow micromolar concentrations

   Effects of (Poly)phenols on Circadian Clock Gene-Mediated Metabolic Homeostasis in Cultured Mammalian Cells: A Scoping Review

   Advances in nutrition (Bethesda, Md.)·Apr 20, 2024

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1. Pivot is associated with genome editing activity in M. cells cells (compared with SpRY) (comparable to SpRY).

   “PIVOT, which achieves editing activity comparable to SpRY in mammalian cells with high specificity.”

   Cellscompared with SpRYmammalian cells

   Compact gene editor enables efficient DNA editing in mice

   Research Square·Nov 9, 2026Preprint

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1. Deoxyadenosine increases T editing outcomes in mammalian cells with glycosylase-derived base editors.

   “supplementation with dA increased T outcomes, albeit at a relatively modest level”

   Cellsin mammalian cells with glycosylase-derived base editors

   Harnessing nucleotide metabolism to control glycosylase base editing outcomes

   Theranostics·Feb 4, 2026

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1. Urolithin A decreases cellular senescence in M. cells cells (Stress-induced senescence; calcium-dependent effect).

   “Similarly, in mammalian cells, UA increases intracellular calcium, enhances mitophagy and mitochondrial metabolism, and mitigates stress-induced senescence in a calcium-dependent manner.”

   CellsStress-induced senescence; calcium-dependent effect

   Urolithin Α modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing

   Autophagy·Sep 13, 2025

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1. Cyc decreases cellular senescence in M. cells cells (etoposide-induced senescence).

   “inhibited etoposide (ETO)-induced cell senescence”

   Cellsetoposide-induced senescence

   β-Cyclocitral from Lavandula angustifolia Mill. Exerts Anti-Aging Effects on Yeasts and Mammalian Cells via Telomere Protection, Antioxidative Stress, and Autophagy Activation

   Antioxidants (Basel, Switzerland)·Jun 12, 2024

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1. Starvation induces mass density in cultured mammalian cell lines.

   “physiological perturbations such as starvation or senescence induce significant shifts in mass density.”

   Cellsin cultured mammalian cell lines

   The uniformity and stability of cellular mass density in mammalian cell culture

   Frontiers in cell and developmental biology·Oct 12, 2022

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1. Extracellular osmolytes are associated with mass density in M. cells cells.

   “mass density can be modulated directly by extracellular osmolytes or by disruptions of the cytoskeleton.”

   Cells

   The uniformity and stability of cellular mass density in mammalian cell culture

   Frontiers in cell and developmental biology·Oct 12, 2022

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