Pivot

Pivot has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Nov 12, 2026: “Compact gene editor enables efficient DNA editing in mice”.

Intervention

1 paper studies it3 findingsUpdated Nov 9, 2026

1 new paper in 30 daysSee all 1 papers on pivot

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

1 lab in 1 country

Animals1

What did studies of pivot find?

Studies of pivot measured 2 outcomes: LDL cholesterol and germline editing.

LDL cholesterol

downin animals1−47% reduction

1 study

Pivot decreases LDL cholesterol (hepatic PCSK9 knockout) (~47% reduction).
“a single AAV vector drove durable hepatic PCSK9 knockout, reducing circulating PCSK9 by ~82% and serum LDL-C by ~47%.”
Animalshepatic PCSK9 knockoutAAV vectora single AAV vector
Compact gene editor enables efficient DNA editing in mice
Research SquareNov 9, 2026Preprint

What is pivot linked with?

Studies link pivot with genome editing activity.

Genome editing activity

no changein M. cells cells1

1 study

Pivot is associated with genome editing activity in M. cells cells (compared with SpRY) (comparable to SpRY).
“PIVOT, which achieves editing activity comparable to SpRY in mammalian cells with high specificity.”
Cellscompared with SpRYmammalian cells
Compact gene editor enables efficient DNA editing in mice
Research SquareNov 9, 2026Preprint

Latest

1 paper in 12 months

Research SquareNov 10

Compact gene editor enables efficient DNA editing in mice

Viral delivery of the editor in mice reduced a cholesterol-regulating protein by about 82% and LDL cholesterol by about 47%.Viral delivery of the editor in mice reduced a cholesterol-regulating protein by about 82% and LDL cholesterol by about 47%.

Preprint: mouse studyInterventions

Paper