Walkability

3 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries
1 finding against

Humans3

Outcomes

Physical activity

no changein humans1upin humans1OR 1.25

2 studies

Walkability has no effect on physical activity in humans.
“Walkability scores were not associated with physical activity and sedentary measurements”
Humanscognitively unimpaired older adults at increased AD riskn = 1,398
Association of neighborhood social and built environment with physical activity in U.S. POINTER
AAIC 2025 abstract23 Dec 2025
Walkability increases physical activity in humans (OR=1.25, p<0.05).
“walkability, healthy food availability, social cohesion, and safety were associated with higher odds of adequate PA (OR=1.56; 1.25; 1.14; 1.23; and 1.11, respectively; all p<0.05).”
Humansn = 2,808
Association of Neighborhood Environment with Physical Activity, Sedentarism, and Body Composition Measures among Young Adults in Puerto Rico
ADA Scientific Sessions 2025 abstract13 Jun 2025

Sedentary behavior

downin humans1OR 1.1

1 study

Walkability decreases sedentary behavior in humans (OR=1.10, p=0.04).
“Notably, greater walkability (OR=1.10, p=0.04), greater safety (OR=1.08, p=0.04), and lower violence (OR=0.83, p=0.04) were associated with greater odds of limited sedentary time.”
Humansn = 2,808
Association of Neighborhood Environment with Physical Activity, Sedentarism, and Body Composition Measures among Young Adults in Puerto Rico
ADA Scientific Sessions 2025 abstract13 Jun 2025

Associations

Depressive symptoms

downin humans1

1 study

Walkability is associated with depressive symptoms in humans.
“higher walkability was marginally associated with lower GDS‐30 scores among individuals in medium‐deprivation areas”
Humansin medium-deprivation areas
Association of neighbourhood walkability with pathophysiological markers and depressive symptoms by area deprivation index and cognitive status in older adults
AAIC 2025 abstract23 Dec 2025

Aβ42

downin humans1

1 study