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Visceral fat removal

Intervention

5 papers7 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 4 independent labs in 1 country
  • Funders: National Institute on Aging and 4 more
  • Animals5

Outcomes

5

Apoptosis

no changein animals1no changein mice1

2 studies

  1. Visceral fat removal has no effect on apoptosis.

    “VFR did not change the expression of the examined genes in KO or N mice.”

    Animalskidney2 months after VFRmales

    Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension

    Age (Dordrecht, Netherlands)23 Mar 2011

  2. Visceral fat removal has no effect on apoptosis in mice.

    “VFR did not change the level of any of the examined proteins.”

    Animalskidneytwo monthsmales

    Renal pro-apoptotic proteins are reduced by growth hormone resistance but not by visceral fat removal

    Biological chemistry11 Mar 2011

More on Apoptosis

Insulin sensitivity

upin mice1

1 study

  1. Visceral fat removal improves insulin sensitivity in mice.

    “Symptomatic males showed reduced vWAT lipogenesis, enhanced hepatic lipolysis, glycolysis, and glycogenesis, lowering liver lipids and improving insulin sensitivity.”

    Animalssymptomaticmales

    Surgical Removal of Visceral Adipose Tissue has Therapeutic Benefit in Male APPNL-F Mice

    bioRxiv : the preprint server for biology11 Aug 2025Preprint

Novel object recognition memory

upin mice1

1 study

  1. Visceral fat removal improves novel object recognition memory in mice.

    “Only symptomatic males improved NOR, linked to elevated hippocampal learning and memory markers.”

    Animalssymptomaticmales

    Surgical Removal of Visceral Adipose Tissue has Therapeutic Benefit in Male APPNL-F Mice

    bioRxiv : the preprint server for biology11 Aug 2025Preprint

Mitochondrial biogenesis (PGC-1α)

no changein mice1

1 study

  1. Visceral fat removal has no effect on mitochondrial biogenesis (PGC-1α) in mice.

    “were not further improved by two other potential life-extending interventions-calorie restriction and visceral fat removal”

    Animalsin GHRKO mice

    Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice

    The journals of gerontology. Series A, Biological sciences and medical sciences29 Nov 2012

More on Mitochondrial biogenesis (PGC-1α)

Lifespan

upin rats1

1 study

  1. Visceral fat removal extends lifespan in rats.

    “VF-removed rats had a significant increase in mean (p < 0.001) and maximum lifespan (p < 0.04)”

    Animalsin AL-fed rats

    Visceral adipose tissue modulates mammalian longevity

    Aging cell18 Mar 2008

Associations

1

Severe renal disease

downin rats1

1 study

  1. Visceral fat removal lowers the risk of severe renal disease in rats.

    “significant reduction in the incidence of severe renal disease (p < 0.01)”

    Animalsin AL-fed rats

    Visceral adipose tissue modulates mammalian longevity

    Aging cell18 Mar 2008

More on Severe renal disease

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