Trilobatin

1. Trilobatin decreases hepatic pathological damage in mice.

   “ameliorated hepatic pathological damage”

   Animalsin high-fat diet-induced miceliver100 mg/kg

   Trilobatin is associated with reduced lipid accumulation in multiple biological models: insights from transcriptomics, molecular docking, and molecular dynamics simulations

   Naunyn-Schmiedeberg's archives of pharmacology·6 May 2026

1. Trilobatin decreases body weight in mice (-10.32%).

   “100 mg/kg TLB decreased body weight by 10.32%”

   Animalsin high-fat diet-induced mice100 mg/kg

   Trilobatin is associated with reduced lipid accumulation in multiple biological models: insights from transcriptomics, molecular docking, and molecular dynamics simulations

   Naunyn-Schmiedeberg's archives of pharmacology·6 May 2026

1. Trilobatin decreases oxidative stress and ROS signalling in worms.

   “alleviated glucotoxicity-induced oxidative stress to some extent”

   Model organismsin high-glucose-induced C. elegans

   Trilobatin is associated with reduced lipid accumulation in multiple biological models: insights from transcriptomics, molecular docking, and molecular dynamics simulations

   Naunyn-Schmiedeberg's archives of pharmacology·6 May 2026

More on Oxidative stress and ROS signalling

1. Trilobatin extends lifespan in worms.

   “prolonged the lifespan of C. elegans”

   Model organismsin high-glucose-induced C. elegans

   Trilobatin is associated with reduced lipid accumulation in multiple biological models: insights from transcriptomics, molecular docking, and molecular dynamics simulations

   Naunyn-Schmiedeberg's archives of pharmacology·6 May 2026

1. Trilobatin inhibits apoptosis in rat cells.

   “Furthermore, TLB, via the SIRT2/PKM2 axis, improved mitochondrial function, supported by the recovery of ATP production, mitochondrial membrane potential, and mitochondrial permeability transition pore integrity, ultimately suppressing GC apoptosis.”

   Cellsin DHT-induced primary rat granulosa cells

   Trilobatin alleviates polycystic ovary syndrome in rats by targeting SIRT2-Mediated PKM2 acetylation in glycolysis and mitochondrial function

   Phytomedicine : international journal of phytotherapy and phytopharmacology·18 Apr 2026

More on Apoptosis

1. Trilobatin decreases polycystic ovary syndrome in rats.

   “TLB administration alleviated estrous cycle disruption, improved ovarian morphology, and normalized serum testosterone, luteinizing hormone, and HOMA-IR index in PCOS rats.”

   Animalsin DHEA-induced PCOS rats

   Trilobatin alleviates polycystic ovary syndrome in rats by targeting SIRT2-Mediated PKM2 acetylation in glycolysis and mitochondrial function

   Phytomedicine : international journal of phytotherapy and phytopharmacology·18 Apr 2026

More on Polycystic ovary syndrome