Time in bed

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans2

Outcomes

Hippocampal volume

downin humans1

1 study

Time in bed decreases hippocampal volume in humans (β = -0.12, 95% CI -0.19, -0.05).
“longer TIB ( β = ‐0.12, 95%CI ‐0.19, ‐0.05), WASO ( β = ‐0.08, 95%CI ‐0.15, ‐0.01), and awakening length ( β = ‐0.10, 95%CI ‐0.17, ‐0.03) were associated with smaller hippocampal volume.”
Humansbrainn = 703
Objective sleep quality and MRI biomarkers of Alzheimer’s Disease in a diverse cohort of older adults
AAIC 2025 abstract23 Dec 2025

Associations

Cognitive impairment

upin humans1RR 1.201

1 study

Time in bed raises the risk of cognitive impairment in humans (RR = 1.201, 95% CI 1.037∼1.389).
“excessive time in bed (> 8 hours/day) in the 80‐90 age group (RR = 1.201, 95% CI 1.037∼1.389, p = 0.014) were associated with an increased risk of cognitive impairment.”
Humans> 8 hours/day
Subjective Sleep Characteristics and Cognitive Impairment from Ages 60 to 90+: A Pooled Analysis of Four Prospective Cohorts
AAIC 2025 abstract25 Dec 2025