7 papers7 findings
Slow walking speed
no changein humans1
Sleep efficiency has no effect on slow walking speed in humans.
“Wearable-estimated sleep efficiency was not associated with frailty, low muscle mass, or slow walking speed.”
HumansOlder outpatients with predominantly cardiometabolic diseasesn = 165
JMIR formative research9 Oct 2026
Low muscle mass
no changein humans1
Sleep efficiency has no effect on low muscle mass in humans.
“Wearable-estimated sleep efficiency was not associated with frailty, low muscle mass, or slow walking speed.”
HumansOlder outpatients with predominantly cardiometabolic diseasesn = 165
JMIR formative research9 Oct 2026
Frailty
no changein humans1
Sleep efficiency has no effect on frailty in humans.
“Wearable-estimated sleep efficiency was not associated with frailty, low muscle mass, or slow walking speed.”
HumansOlder outpatients with predominantly cardiometabolic diseasesn = 165
JMIR formative research9 Oct 2026
Mortality
no changein humans1
Sleep efficiency has no effect on mortality in humans.
“neither measure of sleep efficiency was significant after adjusting for daytime activity”
Humansafter adjusting for daytime activity
DAYTIME ACTIVITY ATTENUATES ASSOCIATIONS BETWEEN SLEEP EFFICIENCY AND MORTALITY AMONG OLDER ADULTS
GSA 2024 abstract31 Dec 2024
Amyloid-beta
downin humans1
Sleep efficiency is associated with amyloid-beta in humans.
“higher depression severity and lower sleep efficiency were associated with greater total Aβ burden”
Humansin APOE ɛ4 carriers
Depression and sleep links to protein build-up varied by genetic risk
Alzheimer's & dementia (Amsterdam, Netherlands)9 Oct 2026
Mortality
downin humans1HR 0.7
Sleep efficiency is associated with mortality in humans (HR 0.70 per 0.1-unit increase, 95% CI 0.57–0.86).
“higher sleep efficiency (HR per 0.1-unit increase, 0.70; 95% CI, 0.57-0.86) were associated with lower all-cause mortality”
Humanscardiovascular-kidney-metabolic stages 1 to 4per 0.1-unit increaseMortality follow-up through 2019n = 3,061
More broken-up rest and activity linked to higher death risk
Sleep health9 Oct 2026
Executive attention
downin humans1
Sleep efficiency is associated with executive attention in humans (β = -18.73, p = .046).
“Sleep efficiency was significantly associated with executive attention after adjusting for education and income (β = -18.73, p =.046).”
Humansafter adjusting for education and incomen = 39
GSA 2024 abstract31 Dec 2024
An observational study of 110 adults aged 65–88 with depression found separate, additive links to amyloid, a protein, only in carriers of a genetic variant.An observational study of 110 adults aged 65–88 with depression found separate, additive links to amyloid, a protein, only in carriers of a genetic variant.
A 0.1-unit higher score for broken-up rest and activity was linked to 1.15 times the death rate among 3,061 adults.A 0.1-unit higher score for broken-up rest and activity was linked to 1.15 times the death rate among 3,061 adults.