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Tetrahydroxystilbene glucoside

Intervention

3 papers11 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 3 independent labs in 1 country
  • Funders: Guangzhou Regenerative Medicine and Health Guangdong Laboratory and 6 more
  • Animals3

Outcomes

11

Epigenetic reprogramming

upin mice1

1 study

  1. Tetrahydroxystilbene glucoside induces epigenetic reprogramming in mice.

    “promoted an epigenetic reprograming that was associated with an improved regenerative capacity and an increased rate of lymphopoiesis.”

    Animalshematopoietic stem cell

    Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2

    Journal of advanced research3 May 2024

Hematopoietic stem cell stemness

upin mice1

1 study

  1. Tetrahydroxystilbene glucoside improves hematopoietic stem cell stemness in mice.

    “TSG supplementation restored the stemness of aging HSCs”

    Animalshematopoietic stem cell

    Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2

    Journal of advanced research3 May 2024

Hematopoietic stem cell and common lymphoid progenitor repopulation potential

upin mice1

1 study

  1. Tetrahydroxystilbene glucoside improves hematopoietic stem cell and common lymphoid progenitor repopulation potential in mice.

    “but also boosted the HSCs/CLPs repopulation potential of aging mice.”

    Animalshematopoietic stem cell and common lymphoid progenitor

    Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2

    Journal of advanced research3 May 2024

Common lymphoid progenitor and B lymphocyte counts

upin mice1

1 study

  1. Tetrahydroxystilbene glucoside increases common lymphoid progenitor and B lymphocyte counts in mice.

    “TSG treatment not only significantly increased the absolute number of common lymphoid progenitors (CLPs) along with B lymphocytes”

    Animals

    Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2

    Journal of advanced research3 May 2024

More on Common lymphoid progenitor and B lymphocyte counts

Mitochondrial biogenesis (PGC-1α)

upin mice1

1 study

  1. Tetrahydroxystilbene glucoside improves mitochondrial biogenesis (PGC-1α) in mice.

    “significant improvement in motor function, bone mineral density, HC-induced organ pathology, and mitochondrial function”

    Animalshigh-calorie diet

    Tetrahydroxystilbene Glucoside Delayed Senile Symptoms in Old Mice via Regulation of the AMPK/SIRT1/PGC-1α Signaling Cascade

    Gerontology25 May 2018

More on Mitochondrial biogenesis (PGC-1α)

Bone mineral density

upin mice1

1 study

  1. Tetrahydroxystilbene glucoside improves bone mineral density in mice.

    “significant improvement in motor function, bone mineral density, HC-induced organ pathology, and mitochondrial function”

    Animalshigh-calorie diet

    Tetrahydroxystilbene Glucoside Delayed Senile Symptoms in Old Mice via Regulation of the AMPK/SIRT1/PGC-1α Signaling Cascade

    Gerontology25 May 2018

More on Bone mineral density

Motor function

upin mice1

1 study

  1. Tetrahydroxystilbene glucoside improves motor function in mice.

    “significant improvement in motor function, bone mineral density, HC-induced organ pathology, and mitochondrial function”

    Animalshigh-calorie diet

    Tetrahydroxystilbene Glucoside Delayed Senile Symptoms in Old Mice via Regulation of the AMPK/SIRT1/PGC-1α Signaling Cascade

    Gerontology25 May 2018

Insulin/IGF-1 signalling

downin mice1

1 study

  1. Tetrahydroxystilbene glucoside decreases insulin/IGF-1 signalling in mice.

    “reduced the levels of neural insulin, insulin-receptor, insulin-like growth factor-1, and insulin-like growth factor-1 receptor in the brain of SAMP8”

    AnimalsSAMP8 micebrain

    Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1

    Neurobiology of aging18 Dec 2014

More on Insulin/IGF-1 signalling

KL

upin mice1

1 study

  1. Tetrahydroxystilbene glucoside increases KL in mice.

    “TSG increased the protein level of neural klotho and reduced the levels of neural insulin, insulin-receptor, insulin-like growth factor-1, and insulin-like growth factor-1 receptor”

    AnimalsSAMP8 micebrain

    Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1

    Neurobiology of aging18 Dec 2014

More on KL

Memory ability

upin mice1

1 study

  1. Tetrahydroxystilbene glucoside improves memory ability in mice.

    “TSG improved the memory ability significantly (p < 0.01, compared with a control group).”

    AnimalsSAMP8 mice

    Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1

    Neurobiology of aging18 Dec 2014

All 11

Lifespan

upin mice1+17% at the most

1 study

  1. Tetrahydroxystilbene glucoside extends lifespan in mice (+17% at the most).

    “TSG prolonged the life span of SAMP8 by 17% at the most (p < 0.01, compared with a control group).”

    AnimalsSAMP8 mice

    Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1

    Neurobiology of aging18 Dec 2014

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