Spatial memory
upin mice1
Tc-g 1005 improves spatial memory in mice.
“expanded SOX2-positive and proliferating NSCs, reduced p16, recovered ASCL1 and improved spatial memory, without changing locomotion or generating DCX-positive neurons.”
AnimalsSubcutaneous administration5 mg/kg, twice daily28 days
A compound expands the brain stem-cell pool in aged mice
bioRxiv15 Oct 2026Preprint
Inflammatory transcriptome
downin mouse cells1
Tc-g 1005 decreases inflammatory transcriptome in mouse cells (More than 90% contraction).
“activation of TGR5 suppressed IL-6 induced p53 and p16 expression, restored proliferation and contracted the inflammatory transcriptome by more than 90%”
CellsIL-6-induced senescencehippocampal neural stem cells
A compound expands the brain stem-cell pool in aged mice
bioRxiv15 Oct 2026Preprint
Neural stem cell proliferation
upin mouse cells1
Tc-g 1005 increases neural stem cell proliferation in mouse cells.
“Primary NSCs treatment with TC-G 1005 increased BrdU incorporation and PCNA in a concentration-dependent manner, and both responses were lost after TGR5 knockdown.”
CellsResponses were lost after TGR5 knockdownhippocampal neural stem cells
A compound expands the brain stem-cell pool in aged mice
bioRxiv15 Oct 2026Preprint
Hippocampal proteomic profile
mixedin mice1
Tc-g 1005 is associated with hippocampal proteomic profile in mice (86 proteins shared between ageing- and treatment-responsive sets).
“Hippocampal proteomic analysis revealed that TC-G 1005 treated aged mice occupied an intermediate, partially rejuvenated position between young and aged proteomes”
AnimalsCompared with young and aged proteomeshippocampus
A compound expands the brain stem-cell pool in aged mice
bioRxiv15 Oct 2026Preprint
In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.