1 paper1 finding
Tc-g 1005
downin mouse cells1
Tc-g 1005 decreases inflammatory transcriptome in mouse cells (More than 90% contraction).
“activation of TGR5 suppressed IL-6 induced p53 and p16 expression, restored proliferation and contracted the inflammatory transcriptome by more than 90%”
CellsIL-6-induced senescencehippocampal neural stem cells
A compound expands the brain stem-cell pool in aged mice
bioRxiv15 Oct 2026Preprint
In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.
Across 193 GTEx and 1,605 Framingham Heart Study participants over 55, females with uncontrolled high blood pressure showed a distinct, suppressed blood transcriptomic…Across 193 GTEx and 1,605 Framingham Heart Study participants over 55, females with uncontrolled high blood pressure showed a distinct, suppressed blood transcriptomic signature.