Sunitinib

Intervention1 paper3 findingsPubChem 5329102ChEBI 38940

  • Cells1

Outcomes

3

SASP expression

downin mice1Very low certainty

1 study

  1. Sunitinib decreases SASP expression in mice.

    Animalsbleomycin-induced lung fibrosislung

    Sunitinib selectively killed senescent cells in the lab · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 5 Oct 2026

SASP expression →

Senescent-cell abundance

downin mice1Very low certainty

1 study

  1. Sunitinib decreases senescent-cell abundance in mice.

    Animalsbleomycin-induced lung fibrosislung

    Sunitinib selectively killed senescent cells in the lab · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 5 Oct 2026

Senescent-cell abundance →

Apoptosis

upin human cells1Very low certainty

1 study

  1. Sunitinib induces apoptosis in human cells.

    Cellssenescent HDFsHDF

    Sunitinib selectively killed senescent cells in the lab · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 5 Oct 2026

Apoptosis →

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Biomedicine & PharmacotherapyCells

Sunitinib selectively killed senescent cells in the lab

A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals.A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals.

Lung

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