Succinate

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute on Aging and 1 more

Cells2

Outcomes

Th17 cytokines

upin human cells2

2 studies

Succinate induces Th17 cytokines in human cells.
“exogenous addition of cell-permeable succinate induced SDH protein in T cells from younger adults and recapitulated the proinflammatory Th17 profile observed in T cells from older adults.”
Cellsin T cells from younger adultsCD4+ T cells
Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation
Aging cell24 Mar 2026
Succinate increases Th17 cytokines in human cells.
“exogenous addition of cell-permeable succinate induced SDH protein in T cells from Y adults, recapitulating the proinflammatory Th17 profile observed in T cells from O adults.”
Cellsin CD4+ T cells from young adults
Metabolic Regulation of Inflammation in Aging
GSA 2025 abstract31 Dec 2025

Latest

17 in 12 months

Physiological Reports6 Oct

Microbial compounds limited muscle loss in aged mice

In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.

Experiments in miceMuscle

Paper

BioFactors2 Oct