Metabolic-Epigenetic Coupling in Cellular Senescence: In Silico Cristae Remodeling Depletes Alpha-Ketoglutarate to Drive KDM4/6 Inhibition and SASP Amplification
bioRxiv
Abstract
Cellular senescence is governed by complex organellar cross-talk, epigenetic remodeling, and non-canonical signaling cascades that drive chronic tissue degeneration. In this work, we formulate a predictive computational systems biology framework to investigate these dynamics.
The paper
Maclos M, Dyer J
bioRxiv · 18 Sep 2026 · CC BY · Preprint, not peer-reviewed
