Th17 cytokines
2 papers3 findings
- Cells2
Interventions
1Succinate
upin human cells2
2 studies
Succinate
upin human cells2
Succinate induces Th17 cytokines in human cells.
“exogenous addition of cell-permeable succinate induced SDH protein in T cells from younger adults and recapitulated the proinflammatory Th17 profile observed in T cells from older adults.”
Cellsin T cells from younger adultsCD4+ T cells
Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation
Aging cell24 Mar 2026
Succinate increases Th17 cytokines in human cells.
“exogenous addition of cell-permeable succinate induced SDH protein in T cells from Y adults, recapitulating the proinflammatory Th17 profile observed in T cells from O adults.”
Cellsin CD4+ T cells from young adults
Metabolic Regulation of Inflammation in Aging
GSA 2025 abstract31 Dec 2025
Upstream
1SUCCINATEDEHYDROGENASE
upin human cells1
1 study
SUCCINATEDEHYDROGENASE
upin human cells1
SUCCINATEDEHYDROGENASE increases Th17 cytokines in human cells.
“SDH activation in T cells from older adults induced heightened oxidation of succinate, disrupted the fumarate-to-succinate ratio, stabilized HIF-1α, and promoted Th17 cytokines.”
CellsSDH activation in T cells from older adultsCD4+ T cells
Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation
Aging cell24 Mar 2026
Latest
2 in 12 monthsAging Cell
Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation
Experiments in human cellsInflammation
GSA 2025 Abstract
Metabolic Regulation of Inflammation in Aging
Experiments in human cellsOxidative phosphorylation
Cell Metabolism
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Experiments in human cellsMetformin