Substrate stiffness

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Australian Research Council and 1 more

Cells3

Outcomes

4

MMP28

upin human cells1

1 study

Substrate stiffness increases MMP28 in human cells.
“Endothelial cells exposed to high shear stress and increased stiffness showed up-regulation of genes such as ICAM1, VCAM1, LAMB3, and MMP28”
Cellshigh shear stress
Decoding vascular aging: Substrate stiffness and shear stress orchestrate endothelial inflammation and remodelling via mechanosensitive pathways
Biomaterials19 Dec 2025

LAMB3

upin human cells1

1 study

Substrate stiffness increases LAMB3 in human cells.
“Endothelial cells exposed to high shear stress and increased stiffness showed up-regulation of genes such as ICAM1, VCAM1, LAMB3, and MMP28”
Cellshigh shear stress
Decoding vascular aging: Substrate stiffness and shear stress orchestrate endothelial inflammation and remodelling via mechanosensitive pathways
Biomaterials19 Dec 2025

VCAM1

upin human cells1

1 study

Substrate stiffness increases VCAM1 in human cells.
“Endothelial cells exposed to high shear stress and increased stiffness showed up-regulation of genes such as ICAM1, VCAM1, LAMB3, and MMP28”
Cellshigh shear stress
Decoding vascular aging: Substrate stiffness and shear stress orchestrate endothelial inflammation and remodelling via mechanosensitive pathways
Biomaterials19 Dec 2025

ICAM1

upin human cells1

1 study

Substrate stiffness increases ICAM1 in human cells.
“Endothelial cells exposed to high shear stress and increased stiffness showed up-regulation of genes such as ICAM1, VCAM1, LAMB3, and MMP28”
Cellshigh shear stress
Decoding vascular aging: Substrate stiffness and shear stress orchestrate endothelial inflammation and remodelling via mechanosensitive pathways
Biomaterials19 Dec 2025

Latest

1 in 12 months

Biomaterials23 Dec

Decoding vascular aging: Substrate stiffness and shear stress orchestrate endothelial inflammation and remodelling via mechanosensitive pathways

Experiments in human cellsExtracellular matrix remodelling

Materials Today Bio19 Nov

Increased substrate stiffness disrupts nuclear-cytoskeletal mechanical coupling in senescent cells

Experiments in human cellsCellular senescence

bioRxiv5 Sep

Substrate stiffness and viscoelasticity influence fibroblast senescence

Preprint: experiments in human cellsCellular senescence