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Substrate viscoelasticity

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Cells1

Outcomes

1

Cellular senescence

upin human cells1

1 study

  1. Substrate viscoelasticity induces cellular senescence in human cells.

    “soft (2 kPa) viscoelastic substrates promoting both the onset and amplification of senescence, even in the absence of genotoxic stress.”

    Cellssoft (2 kPa) viscoelastic substrates, even in the absence of genotoxic stress

    Substrate stiffness and viscoelasticity influence fibroblast senescence

    bioRxiv : the preprint server for biology27 Aug 2025Preprint

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