Somatotropin
4 papers8 findings
- 3 independent labs in 2 countries
- 1 finding against
- Funders: National Institute of Diabetes and Digestive and Kidney Diseases and 6 more
- Animals4
Outcomes
6Lifespan
downin mice1no changein rats1downin rats1
2 studies
Lifespan
downin mice1no changein rats1downin rats1
Somatotropin shortens lifespan in mice (707 ± 9 vs 987 ± 24 d).
“Ames dwarf mice survived 987 ± 24 d (median), longer than nonmutant control mice (664 ± 48), but GH-injected dwarf mice did not differ from controls (707 ± 9).”
Animalsin hypopituitary Ames dwarf mice6 wk
FASEB journal : official publication of the Federation of American Societies for Experimental Biology18 Aug 2010
Somatotropin has no effect on lifespan in rats (639 days vs 661 days (NS)).
“The average life span of the lean rats was 661 days and was unaffected by STH treatment (639 days, NS) or gender.”
Animalsin lean Zucker rats2 mg/d
Experimental biology and medicine (Maywood, N.J.)1 Jan 2006
Somatotropin shortens lifespan in rats (349 days vs 435 days).
“STH treatment of the obese rats resulted in a further reduction of life span (349 days, P < 0.02).”
Animalsin obese Zucker rats2 mg/d
Experimental biology and medicine (Maywood, N.J.)1 Jan 2006
Total adiponectin
downin mice1
1 study
Total adiponectin
downin mice1
Somatotropin decreases total adiponectin in mice.
“rbGH, but not IGF1, decreased circulating total and HMW adiponectin levels.”
Animalsin mice
Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?
The Journal of endocrinology25 Feb 2013
Cadmium resistance
downin mouse cells1
1 study
Cadmium resistance
downin mouse cells1
Somatotropin decreases cadmium resistance in mouse cells (LD50 5.8 ± 0.9 vs 9.98 ± 1.7).
“GH injections into Ames dwarf mice restored the normal level of cadmium resistance (LD(50)=5.8 ± 0.9).”
Cellsin hypopituitary Ames dwarf mice6 wk
FASEB journal : official publication of the Federation of American Societies for Experimental Biology18 Aug 2010
Carcass fat
downin rats1−21%
1 study
Carcass fat
downin rats1−21%
Somatotropin decreases carcass fat in rats (-21%).
“decreased carcass fat by 21% (P < 0.05)”
Animalsacross phenotypes2 mg/d4 weeks
Experimental biology and medicine (Maywood, N.J.)1 Jan 2006
Muscle weight
upin rats1+14%
1 study
Muscle weight
upin rats1+14%
Somatotropin increases muscle weight in rats (+14%).
“muscle weights by 14%”
Animalsacross phenotypes2 mg/d4 weeks
Experimental biology and medicine (Maywood, N.J.)1 Jan 2006
Growth rate
upin rats1+159%
1 study
Growth rate
upin rats1+159%
Somatotropin increases growth rate in rats (+159%).
“Across phenotypes, STH treatment increased the growth rate by 159%”
Animalsacross phenotypes2 mg/d4 weeks
Experimental biology and medicine (Maywood, N.J.)1 Jan 2006