Sodium hydrosulfide

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Animals2

Outcomes

Pial artery dilation

upin rats1

1 study

Sodium hydrosulfide induces pial artery dilation in rats.
“In vivo micrography was used to study dilatory responses of arteries ranging in size from 8 to 86 microns to the effect of H2S donor (sodium hydrosulfide solution, NaHS, 3·10-5 М)”
Animalsin Sprague-Dawley ratspial arteries3·10-5 M
H2S as an activator of the NO-sGC signaling pathway in dilation of cerebral vessels: changes in aging
Advances in gerontology = Uspekhi gerontologii1 Jan 2025

Cellular senescence

downin mouse cells1

1 study

Sodium hydrosulfide decreases cellular senescence in mouse cells.
“Exogenous H2S donor NaHS-mediated SIRT3 augmentation rescued the senescent phenotypes of BMSCs.”
Cellsbone marrow mesenchymal stem cells
S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis
Pharmacological research3 May 2023