Small extracellular vesicles

1. Small extracellular vesicles decrease inflammation in cells.

   “small extracellular vesicles (sEV) isolated from young human donors ameliorate inflammation and the biogenesis of resolvins both in different cell models and in aged mice.”

   Cellsdifferent cell modelssmall extracellular vesicles isolated from young human donors

   The resolvin D and E biogenesis pathway regulates senescence and ageing

   bioRxiv (Cold Spring Harbor Laboratory)·26 Jan 2026Preprint

2. Small extracellular vesicles decrease inflammation in mice.

   “small extracellular vesicles (sEV) isolated from young human donors ameliorate inflammation and the biogenesis of resolvins both in different cell models and in aged mice.”

   Animalssmall extracellular vesicles isolated from young human donors

   The resolvin D and E biogenesis pathway regulates senescence and ageing

   bioRxiv (Cold Spring Harbor Laboratory)·26 Jan 2026Preprint

More on Inflammation

1. Small extracellular vesicles decrease cell proliferation in human cells.

   “senescent sEVs conferred a senescent-like phenotype on recipient cells, resulting in reduced proliferation and enhanced survival.”

   Cellsrecipient UC-MSCs treated with senescent sEVs

   Nanosized diesel exhaust particles induce mesenchymal stem cell senescence and alter small extracellular vesicle microRNA profiles: Implications for their functional properties

   Ecotoxicology and environmental safety·5 Jan 2026

1. Small extracellular vesicles have no effect on CXCL8 expression in human cells.

   “albeit not stimulating the expression of IL-8.”

   Cellsproliferating recipient cellsisolated from p16 INK4A-expressing cellsfibroblast

   p16 INK4A expression induces paracrine senescence via small extracellular vesicles

   bioRxiv (Cold Spring Harbor Laboratory)·11 Dec 2025Preprint

More on CXCL8 expression

1. Small extracellular vesicles induce DNA damage response in human cells.

   “sEV isolated from p16 INK4A cells are able to mediate paracrine senescence by inducing a growth arrest and DNA damage response in proliferating cells”

   Cellsproliferating recipient cellsisolated from p16 INK4A-expressing cellsfibroblast

   p16 INK4A expression induces paracrine senescence via small extracellular vesicles

   bioRxiv (Cold Spring Harbor Laboratory)·11 Dec 2025Preprint

More on DNA damage response

1. Small extracellular vesicles induce growth arrest in human cells.

   “sEV isolated from p16 INK4A cells are able to mediate paracrine senescence by inducing a growth arrest and DNA damage response in proliferating cells”

   Cellsproliferating recipient cellsisolated from p16 INK4A-expressing cellsfibroblast

   p16 INK4A expression induces paracrine senescence via small extracellular vesicles

   bioRxiv (Cold Spring Harbor Laboratory)·11 Dec 2025Preprint

1. Small extracellular vesicles induce paracrine senescence in human cells.

   “sEV isolated from p16 INK4A cells are able to mediate paracrine senescence”

   Cellsproliferating recipient cellsisolated from p16 INK4A-expressing cellsfibroblast

   p16 INK4A expression induces paracrine senescence via small extracellular vesicles

   bioRxiv (Cold Spring Harbor Laboratory)·11 Dec 2025Preprint