Skev@aav

1. Skev@aav improves immune response in mice.

   “enhanced CD8+ T-cell infiltration, decreased regulatory T cells, and promoted memory T-cell differentiation.”

   Animalsin combination with anti-PD-1 in a murine splenic liver-metastasis model

   Targeting p21-High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2 Jul 2026

More on Immune response

1. Skev@aav decreases tumor burden in mice.

   “where SKEV@AAV reduced tumor burden, enhanced CD8+ T-cell infiltration, decreased regulatory T cells, and promoted memory T-cell differentiation.”

   Animalsin a murine splenic liver-metastasis model

   Targeting p21-High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2 Jul 2026

1. Skev@aav decreases hepatocellular carcinoma in mice.

   “In an orthotopic PVTT model, SKEV@AAV showed single-agent antitumor activity and attenuated SASP-associated inflammatory remodeling.”

   Animalsin an orthotopic PVTT model

   Targeting p21-High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2 Jul 2026

More on Hepatocellular carcinoma