Retsat-silenced senescent synovial mesenchymal stem cells

1 paper2 findings

1 lab in 1 country

Funders: National Natural Science Foundation of China and 1 more

Humans1

Outcomes

2

P21

downin mice1

1 study

Retsat-silenced senescent synovial mesenchymal stem cells decrease P21 in mice (-0.103 [-0.162, -0.045]).
“levels of senescence marker p21 (cartilage -0.103 [-0.162, -0.045] synovial -0.087, [-0.141, -0.033])”
Animalsmurine OA modelcartilage
Retsat promotes synovial mesenchymal stem cell senescence and aggravates osteoarthritis by inhibiting the PPARγ/RXR heterodimerization pathway
Osteoarthritis and cartilage1 Jul 2026

Osteoarthritis

downin mice1

1 study

Retsat-silenced senescent synovial mesenchymal stem cells decrease osteoarthritis in mice.
“Retsat-silenced senescent SMSCs ameliorated OA progression in middle-aged mice, significantly reducing OARSI scores”
Animalsmurine OA model
Retsat promotes synovial mesenchymal stem cell senescence and aggravates osteoarthritis by inhibiting the PPARγ/RXR heterodimerization pathway
Osteoarthritis and cartilage1 Jul 2026

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Retsat promotes synovial mesenchymal stem cell senescence and aggravates osteoarthritis by inhibiting the PPARγ/RXR heterodimerization pathway

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