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Ramelteon

Intervention

1 paper3 findings

PubChem 208902ChEBI 109549MeSH C495910

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

3

Interleukin-1β

downin mice1

1 study

  1. Ramelteon decreases interleukin-1β in mice.

    “ramelteon significantly reduced isoflurane-induced elevation of interleukin-1β in the prefrontal cortex but not in the hippocampus.”

    Animalsafter abdominal laparotomy under 2 h isoflurane anesthesiap.o.prefrontal cortex0.3 mg/kg7 days

    Ramelteon Ameliorates Isoflurane-Induced Hyperactivity and Social-Recognition Impairment in Aged Mice

    Journal of integrative neuroscience15 Oct 2025

More on Interleukin-1β

Social recognition

upin mice1

1 study

  1. Ramelteon improves social recognition in mice.

    “Pretreatment with ramelteon at a dose of 0.3 mg/kg, but not 0.03 mg/kg, attenuated postoperative hyperactivity and preserved normal social recognition.”

    Animalsafter abdominal laparotomy under 2 h isoflurane anesthesiap.o.0.3 mg/kg7 days

    Ramelteon Ameliorates Isoflurane-Induced Hyperactivity and Social-Recognition Impairment in Aged Mice

    Journal of integrative neuroscience15 Oct 2025

Hyperactivity

downin mice1

1 study

  1. Ramelteon decreases hyperactivity in mice.

    “Pretreatment with ramelteon at a dose of 0.3 mg/kg, but not 0.03 mg/kg, attenuated postoperative hyperactivity”

    Animalsafter abdominal laparotomy under 2 h isoflurane anesthesiap.o.0.3 mg/kg7 days

    Ramelteon Ameliorates Isoflurane-Induced Hyperactivity and Social-Recognition Impairment in Aged Mice

    Journal of integrative neuroscience15 Oct 2025

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