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R55

Intervention

1 paper3 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Buck Institute for Research on Aging and others
  • Model organisms1

Outcomes

3

Endolysosomal defects

downin human cells1

1 study

  1. R55 protects against endolysosomal defects in human cells.

    “R55 rescued lifespan and neurodegeneration in mtd-deficient flies and endolysosomal defects in fibroblasts from patients with lethal loss-of-function of OXR1 variants.”

    Cellsin fibroblasts from patients with lethal loss-of-function of OXR1 variants

    OXR1 maintains the retromer to delay brain aging under dietary restriction

    Nature communications11 Jan 2024

Neurodegenerative disease

downin flies1

1 study

  1. R55 protects against neurodegenerative disease in flies.

    “pharmacological restabilization with R55 rescued lifespan and neurodegeneration in mtd-deficient flies”

    Model organismsin mtd-deficient flies

    OXR1 maintains the retromer to delay brain aging under dietary restriction

    Nature communications11 Jan 2024

More on Neurodegenerative disease

Lifespan

upin flies1

1 study

  1. R55 improves lifespan in flies.

    “Overexpression of retromer genes or pharmacological restabilization with R55 rescued lifespan and neurodegeneration in mtd-deficient flies”

    Model organismsin mtd-deficient flies

    OXR1 maintains the retromer to delay brain aging under dietary restriction

    Nature communications11 Jan 2024

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