Puerarin + tempo-modified beta-cyclodextrin

1. Puerarin + tempo-modified beta-cyclodextrin decreases cellular senescence in mice.

   “The P@TCD could mitigate the ROS accumulation, reduce DNA damage, promote cell cycle progression, and attenuate cellular senescence in the corneal epithelium”

   Animalsin DEDcorneal epithelium

   Antioxidant and anti-senescence supramolecular complexes for managing dry eye diseases

   Bioactive materials·13 Jun 2026

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1. Puerarin + tempo-modified beta-cyclodextrin decreases corneal epithelial defects in mice.

   “P@TCD demonstrated favorable therapeutic efficacy by reversing corneal epithelial defects”

   Animalsin DED mouse modelscorneal epithelium

   Antioxidant and anti-senescence supramolecular complexes for managing dry eye diseases

   Bioactive materials·13 Jun 2026

1. Puerarin + tempo-modified beta-cyclodextrin improves tear break-up time in mice (> 5.3 s vs < 2.8 s).

   “improving tear film stability with TBUT values of more than 5.3 s, compared to the DED models of less than 2.8 s”

   Animalsin DED mouse modelstear film

   Antioxidant and anti-senescence supramolecular complexes for managing dry eye diseases

   Bioactive materials·13 Jun 2026

More on Tear break-up time