Pomhex

1. Pomhex decreases osteoarthritis in mice.

   “POMHEX disrupted ENO2-GNL3 binding, restored p53 degradation, reduced senescence markers in vitro, and mitigated cartilage degradation, subchondral bone sclerosis, and pain in aged mice.”

   Animalsin aged mice16 weeks

   Enolase 2-mediated lactylation-dependent disruption of the GNL3-MDM2-p53 axis in age-related osteoarthritis

   Cellular & molecular biology letters·26 May 2026

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