Subchondral bone sclerosis

1 paper1 finding

Animals1

Interventions

1

Dasatinib + quercetin

downin mice1

1 study

Dasatinib + quercetin inhibits subchondral bone sclerosis in mice.
“Administration of D + Q to OA mice effectively cleared senescent BMSCs, reduced osteocalcin expression in subchondral bone, inhibited subchondral bone sclerosis, and alleviated OA progression.”
Animalsin OA micesubchondral bone
Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype
Stem cell research & therapy27 Nov 2025

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