Polyethylene microplastics

1. Polyethylene microplastics induce cellular senescence in cells.

   “At higher concentrations (500 μg/mL), both cell lines demonstrated that PEMPs induce apoptosis and senescence”

   Cellshigher concentrations (500 μg/mL)500 μg/mL

   Tracing the cellular consequences of polyethylene microplastics: senescence and apoptosis in A549 and Raw 264.7 macrophage cells

   Chemico-biological interactions·9 Dec 2025

2. Polyethylene microplastics induce cellular senescence in cells.

   “PE-MPs significantly up-regulated MMP13, P53 and P21 while down-regulated COL2A1, NAT10, GPX4 and SLC7A11 (P < 0.05).”

   Cellsvia M0-MPs-exo

   Polyethylene microplastics transported to nucleus pulposus cells via macrophages-derived exosomes, and promote intervertebral disc degeneration through NAT10/SLC7A11 and ac4C modification

   Ecotoxicology and environmental safety·31 Oct 2025

More on Cellular senescence

1. Polyethylene microplastics induce apoptosis in cells.

   “At higher concentrations (500 μg/mL), both cell lines demonstrated that PEMPs induce apoptosis and senescence”

   Cellshigher concentrations (500 μg/mL)500 μg/mL

   Tracing the cellular consequences of polyethylene microplastics: senescence and apoptosis in A549 and Raw 264.7 macrophage cells

   Chemico-biological interactions·9 Dec 2025

More on Apoptosis

1. Polyethylene microplastics increase oxidative stress and ROS signalling in cells.

   “increased ROS production and mitochondrial damage in a dose- and time-dependent manner”

   Cellsexposure (50-500 μg/mL)50-500 μg/mL

   Tracing the cellular consequences of polyethylene microplastics: senescence and apoptosis in A549 and Raw 264.7 macrophage cells

   Chemico-biological interactions·9 Dec 2025

More on Oxidative stress and ROS signalling

1. Polyethylene microplastics decrease cell viability in cells.

   “Our findings indicate that exposure to PEMPs significantly reduced cell viability”

   Cellsexposure (50-500 μg/mL)50-500 μg/mL

   Tracing the cellular consequences of polyethylene microplastics: senescence and apoptosis in A549 and Raw 264.7 macrophage cells

   Chemico-biological interactions·9 Dec 2025

1. Polyethylene microplastics induce ferroptosis in cells.

   “PE-MPs significantly up-regulated MMP13, P53 and P21 while down-regulated COL2A1, NAT10, GPX4 and SLC7A11 (P < 0.05).”

   Cellsvia M0-MPs-exo

   Polyethylene microplastics transported to nucleus pulposus cells via macrophages-derived exosomes, and promote intervertebral disc degeneration through NAT10/SLC7A11 and ac4C modification

   Ecotoxicology and environmental safety·31 Oct 2025

More on Ferroptosis