Poliumoside

1. Poliumoside increases autophagy in human cells.

   “mitigating H2O2-induced suppression of autophagy and improving cellular senescence”

   Cellsin H2O2-treated HUVECs

   Poliumoside attenuates endothelial senescence and atherosclerosis by regulating MKRN2-mediated autophagy via the PI3K/AKT/ mTOR pathway

   International immunopharmacology·25 Jan 2026

More on Autophagy

1. Poliumoside decreases oxidative stress and ROS signalling in human cells.

   “Pol suppressed the upregulation of p16, p21, and p53 in senescent HUVECs, decreased Senescence-Associated Secretory Phenotype (SASP) levels, improved autophagy dysfunction, and reduced oxidative stress.”

   Cellsin senescent HUVECs

   Poliumoside attenuates endothelial senescence and atherosclerosis by regulating MKRN2-mediated autophagy via the PI3K/AKT/ mTOR pathway

   International immunopharmacology·25 Jan 2026

More on Oxidative stress and ROS signalling

1. Poliumoside decreases cellular senescence in mice.

   “thereby attenuating vascular senescence and atherosclerotic lesions”

   Animalsin ApoE-/- miceaorta

   Poliumoside attenuates endothelial senescence and atherosclerosis by regulating MKRN2-mediated autophagy via the PI3K/AKT/ mTOR pathway

   International immunopharmacology·25 Jan 2026

More on Cellular senescence

1. Poliumoside protects against atherosclerosis in mice.

   “Pol reduced senescence marker expression and SA-β-gal-positive area in aortic tissue, and alleviated autophagy dysfunction, thereby attenuating vascular senescence and atherosclerotic lesions.”

   Animalsin ApoE-/- miceaorta

   Poliumoside attenuates endothelial senescence and atherosclerosis by regulating MKRN2-mediated autophagy via the PI3K/AKT/ mTOR pathway

   International immunopharmacology·25 Jan 2026

More on Atherosclerosis