PNU-282987

1. PNU-282987 inhibits cellular senescence in cells.

   “RNA-seq confirmed that PNU treatment normalised gene expression profiles associated with endoplasmic reticulum stress and cellular senescence.”

   Cellshyperglycaemic conditions

   α7 Nicotinic acetylcholine receptor activation rescues mitochondrial dysfunction in gestational diabetes mellitus by competing with p66Shc for VDAC1 binding

   Diabetologia·15 Dec 2025

More on Cellular senescence

1. PNU-282987 decreases oxidative stress and ROS signalling in cells.

   “Pharmacological activation of α7nAChR with PNU or GTS-21 restored α7nAChR-VDAC1 coupling, attenuated p66Shc-mediated oxidative stress and reversed mitochondrial Ca2+ overload.”

   Cellshyperglycaemic conditions

   α7 Nicotinic acetylcholine receptor activation rescues mitochondrial dysfunction in gestational diabetes mellitus by competing with p66Shc for VDAC1 binding

   Diabetologia·15 Dec 2025

More on Oxidative stress and ROS signalling

1. PNU-282987 activates NRF2–KEAP1 antioxidant response in rats.

   “effective activation of the α7nAChR mediated Nrf2/HO-1 signaling pathway and antioxidant activity by specific agonist, PNU282987”

   Animals

   Targeting α7nAChR mitigates vascular aging and endothelial cell senescence through inhibiting oxidative stress and inflammation via α7nAChR/Nrf2/HO-1 signaling pathway

   Archives of gerontology and geriatrics·28 Oct 2025

More on NRF2–KEAP1 antioxidant response

1. PNU-282987 decreases senescence-associated beta-galactosidase in rats.

   “decreased senescence-associated β-galactosidase activity, phosphorylation of H2A.XSer139, expression of p21 and p16INK4a and inflammation”

   Animals

   Targeting α7nAChR mitigates vascular aging and endothelial cell senescence through inhibiting oxidative stress and inflammation via α7nAChR/Nrf2/HO-1 signaling pathway

   Archives of gerontology and geriatrics·28 Oct 2025

More on Senescence-associated beta-galactosidase

1. PNU-282987 protects against vascular aging in rats.

   “Activation of α7nAChR alleviated vascular aging in aged rats, as evidenced by improving endothelium-dependent vasodilatation and endothelial continuity”

   Animals

   Targeting α7nAChR mitigates vascular aging and endothelial cell senescence through inhibiting oxidative stress and inflammation via α7nAChR/Nrf2/HO-1 signaling pathway

   Archives of gerontology and geriatrics·28 Oct 2025