PKI-402

1. PKI-402 decreases γH2AX foci in human cells.

   “Pharmacological inhibition of PI3K/mTOR mitigates cigarette smoke-induced senescence and SASP in oral fibroblasts, reducing DNA damage and inflammatory signaling.”

   Cellsin cigarette smoke extract-exposed human oral fibroblasts10−7-10−9 M

   PI3K/mTOR inhibition attenuates cigarette smoke-induced senescence and SASP in oral fibroblasts: implications for tumor microenvironment remodeling

   Frontiers in cell and developmental biology·29 Apr 2026

More on γH2AX foci

1. PKI-402 decreases senescence-associated secretory phenotype (SASP) in human cells.

   “PKI402 significantly attenuated these changes in a dose-dependent manner, with the highest concentrations showing statistically significant reductions across all endpoints.”

   Cellsin cigarette smoke extract-exposed human oral fibroblasts10−7-10−9 M

   PI3K/mTOR inhibition attenuates cigarette smoke-induced senescence and SASP in oral fibroblasts: implications for tumor microenvironment remodeling

   Frontiers in cell and developmental biology·29 Apr 2026

More on Senescence-associated secretory phenotype (SASP)

1. PKI-402 decreases cellular senescence in human cells.

   “PKI402 significantly attenuated these changes in a dose-dependent manner, with the highest concentrations showing statistically significant reductions across all endpoints.”

   Cellsin cigarette smoke extract-exposed human oral fibroblasts10−7-10−9 M

   PI3K/mTOR inhibition attenuates cigarette smoke-induced senescence and SASP in oral fibroblasts: implications for tumor microenvironment remodeling

   Frontiers in cell and developmental biology·29 Apr 2026

More on Cellular senescence