Phlorizin

1. Phlorizin decreases cellular senescence in mouse cells.

   “Morphological assessment verified the return to a typical fibroblast-like cell structure.”

   Cellshigh glucose-exposed 3T3-L1 adipocytes

   Development of Phlorizin-Loaded Lipid–Polymeric Hybrid Nanoparticles: Pharmacokinetic and Drug-Likeness Prediction with In Vitro Anti-Senescence Assessment

   Research Square·3 Aug 2026Preprint

More on Cellular senescence

1. Phlorizin decreases senescence-associated beta-galactosidase in mouse cells.

   “The Phlorizin nanosuspension offered dose-dependent defense against cellular senescence, demonstrated by a decrease in SA-β-Gal-positive cells at higher concentrations.”

   Cellshigh glucose-exposed 3T3-L1 adipocytes

   Development of Phlorizin-Loaded Lipid–Polymeric Hybrid Nanoparticles: Pharmacokinetic and Drug-Likeness Prediction with In Vitro Anti-Senescence Assessment

   Research Square·3 Aug 2026Preprint

More on Senescence-associated beta-galactosidase

1. Phlorizin activates fatty acid β-oxidation in worms.

   “significantly increased the expression of fatty acid metabolism-related genes nhr-49, acs-2, and cpt-5”

   Model organismsin Caenorhabditis elegans

   Phlorizin Ameliorates Amyloid-β Toxicity and Enhances Fatty Acid β-Oxidation in Caenorhabditis elegans via NHR-49-Dependent Pathway

   International journal of molecular sciences·23 Sep 2025

More on Fatty acid β-oxidation

1. Phlorizin decreases lipid accumulation in worms.

   “PHZ also reduced lipid accumulation in worms”

   Model organismsin Caenorhabditis elegans

   Phlorizin Ameliorates Amyloid-β Toxicity and Enhances Fatty Acid β-Oxidation in Caenorhabditis elegans via NHR-49-Dependent Pathway

   International journal of molecular sciences·23 Sep 2025

1. Phlorizin improves paraquat resistance in worms.

   “enhanced performance in lifespan, heat stress, ROS, and paraquat assays and chronic paraquat assays”

   Model organismsin Caenorhabditis elegans under paraquat stress

   Phlorizin Ameliorates Amyloid-β Toxicity and Enhances Fatty Acid β-Oxidation in Caenorhabditis elegans via NHR-49-Dependent Pathway

   International journal of molecular sciences·23 Sep 2025

1. Phlorizin extends lifespan in worms.

   “PHZ improved worms' survival and delayed senescence, as demonstrated by enhanced performance in lifespan”

   Model organismsin Caenorhabditis elegans

   Phlorizin Ameliorates Amyloid-β Toxicity and Enhances Fatty Acid β-Oxidation in Caenorhabditis elegans via NHR-49-Dependent Pathway

   International journal of molecular sciences·23 Sep 2025