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Phenylboric acid-grafted hyaluronic acid hydrogel loaded with TIMP3

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Chinese Medicine Research Program of Zhejiang Province and 3 more
  • Animals1

Outcomes

1

Intervertebral disc degeneration

downin rats1

1 study

  1. Phenylboric acid-grafted hyaluronic acid hydrogel loaded with TIMP3 protects against intervertebral disc degeneration in rats.

    “In vivo, it decreased ROS accumulation, inflammatory M1 macrophages, matrix degradation, and neovascularization, significantly ameliorating IDD pathology.”

    Animalsin vivo rat model of IDD

    Synergistic reversal of inflammation-mediated degeneration in intervertebral discs: Phenylboric acid-grafted hyaluronic acid hydrogel as an anti-oxidative vehicle for Timp-3 delivery and promotion of extracellular matrix synthesis

    Acta biomaterialiaJun 6, 2025

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