PF-5190457

1 paper2 findings

1 lab in 1 country

Funders: Congressionally Directed Medical Research Programs and 6 more

Animals1

Outcomes

2

Body weight

downin mice1

1 study

PF-5190457 decreases body weight in mice.
“PF-5190457 also reduced body weight and adiposity, which were not observed with GHSR-1a deletion.”
Animalsmales
Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice
Aging cell1 Apr 2026

Endurance

upin mice1

1 study

PF-5190457 improves endurance in mice.
“PF-5190457 mimicked the effects of GHSR-1a deletion, including improved endurance and increased markers of mitochondrial biogenesis (PGC-1α) and different mitophagy markers (LC3II and Bnip3).”
Animalsskeletal musclemales
Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice
Aging cell1 Apr 2026

Latest

1 in 12 months

Aging Cell16 Apr

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice

Experiments in miceMuscle