Perturbed cyclic strain

1. Perturbed cyclic strain decreases emerin in mouse cells.

   “mechanical induction of premature senescence was associated with decreases in the nuclear envelope protein emerin”

   Cellsmechanical induction of premature senescence

   Perturbed cyclic strain results in a mechanically-induced, premature senescent phenotype in cardiac fibroblasts

   bioRxiv (Cold Spring Harbor Laboratory)·17 Mar 2025Preprint

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1. Perturbed cyclic strain induces DNA damage response in mouse cells.

   “led to a senescence-like phenotype, including cell cycle, lamin B expression, and DNA damage”

   Cellsmimicking an injurious hypertrophic or fibrotic response

   Perturbed cyclic strain results in a mechanically-induced, premature senescent phenotype in cardiac fibroblasts

   bioRxiv (Cold Spring Harbor Laboratory)·17 Mar 2025Preprint

More on DNA damage response

1. Perturbed cyclic strain induces cellular senescence in mouse cells.

   “Loss of stretch magnitude and increase in frequency, mimicking an injurious hypertrophic or fibrotic response, led to a senescence-like phenotype”

   Cellsmimicking an injurious hypertrophic or fibrotic response

   Perturbed cyclic strain results in a mechanically-induced, premature senescent phenotype in cardiac fibroblasts

   bioRxiv (Cold Spring Harbor Laboratory)·17 Mar 2025Preprint

More on Cellular senescence