Perfluorooctane sulfonic acid
Intervention3 papers4 findingsPubChem 74483ChEBI 39421
- Humans2
Outcomes
3MMP3
downin human cells1Low certainty
1 study
MMP3
downin human cells1Low certainty
Perfluorooctane sulfonic acid decreases MMP3 in human cells.
Cellstrabecular meshwork cells
PFAS exposures link to glaucoma and cataract risks · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 30 Sep 2026
PI3K–AKT signalling
upin human cells1Low certainty
1 study
PI3K–AKT signalling
upin human cells1Low certainty
Perfluorooctane sulfonic acid activates PI3K–AKT signalling in human cells.
Cellstrabecular meshwork cells
PFAS exposures link to glaucoma and cataract risks · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 30 Sep 2026
Skin and blood clock
downin humans1Low certainty
1 study
Skin and blood clock
downin humans1Low certainty
Perfluorooctane sulfonic acid decreases skin and blood clock in humans (β= -0.02 years, 95% CI -0.04, -0.00).
Humanswhole blood
Plasma per- and polyfluoroalkyl substance (PFAS) concentrations in mid-childhood and associations with DNA methylation and epigenetic aging through early adolescence · Environmental research · 28 Sep 2026
Associations
1Glaucoma
upin humans1Low certainty
1 study
Glaucoma
upin humans1Low certainty
Perfluorooctane sulfonic acid raises the risk of glaucoma in humans.
HumansNHANES cross-sectional analysis and Mendelian randomization
PFAS exposures link to glaucoma and cataract risks · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 30 Sep 2026
Latest
3PFAS exposures link to glaucoma and cataract risks
An analysis of 2005–2008 NHANES data, Mendelian randomization, and cell assays linked PFOS exposure to glaucoma risk through PI3K/Akt signaling.An analysis of 2005–2008 NHANES data, Mendelian randomization, and cell assays linked PFOS exposure to glaucoma risk through PI3K/Akt signaling.