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Pediococcus acidilactici

Intervention

3 papers study it8 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 3 independent labs in 3 countries
  • Funders: Agencia Estatal de Investigación and 6 more
  • Model organisms3

Outcomes

6

Lifespan

upin worms3

3 studies

  1. Pediococcus acidilactici extends lifespan in worms.

    “PA promoted a significantly extended longevity of wild-type C. elegans.”

    Model organismswild-type

    Pediococcus acidilactici Promotes the Longevity of C. elegans by Regulating the Insulin/IGF-1 and JNK/MAPK Signaling, Fat Accumulation and Chloride Ion

    Frontiers in nutritionApr 1, 2022

  2. Pediococcus acidilactici extends lifespan in worms (>2 days median survival).

    “extending the nematode median survival (>2 days in comparison with untreated control worms)”

    Model organismsunder high-glucose condition

    Pediococcus acidilactici CECT9879 (pA1c) Counteracts the Effect of a High-Glucose Exposure in C. elegans by Affecting the Insulin Signaling Pathway (IIS)

    International journal of molecular sciencesFeb 28, 2022

  3. Pediococcus acidilactici extends lifespan in worms.

    “A Caenorhabditis elegans experiment was also performed to assess the effectiveness of P. acidilactici MNL5 supplementation to increase life span compared to E. coli supplementation (DAF-2 and LIU1 models) (p < 0.05).”

    Model organismscompared to E. coli supplementation (DAF-2 and LIU1 models)

    Anti-Obesity Efficacy of Pediococcus acidilactici MNL5 in Canorhabditis elegans Gut Model

    International journal of molecular sciencesJan 24, 2022

Fat accumulation

downin worms1

1 study

  1. Pediococcus acidilactici decreases fat accumulation in worms.

    “reducing the fat accumulation in C. elegans.”

    Model organisms

    Pediococcus acidilactici Promotes the Longevity of C. elegans by Regulating the Insulin/IGF-1 and JNK/MAPK Signaling, Fat Accumulation and Chloride Ion

    Frontiers in nutritionApr 1, 2022

More on Fat accumulation

Oxidative stress and ROS signaling

downin worms1

1 study

  1. Pediococcus acidilactici decreases oxidative stress and ROS signaling in worms.

    “PA reduced the reactive oxygen species (ROS) levels”

    Model organisms

    Pediococcus acidilactici Promotes the Longevity of C. elegans by Regulating the Insulin/IGF-1 and JNK/MAPK Signaling, Fat Accumulation and Chloride Ion

    Frontiers in nutritionApr 1, 2022

More on Oxidative stress and ROS signaling

Reactive oxygen species

downin worms1−20%

1 study

  1. Pediococcus acidilactici decreases reactive oxygen species in worms (-20%).

    “treatment with pA1c counteracted the effect of the high glucose by reducing reactive oxygen species by 20%”

    Model organismsunder high-glucose condition

    Pediococcus acidilactici CECT9879 (pA1c) Counteracts the Effect of a High-Glucose Exposure in C. elegans by Affecting the Insulin Signaling Pathway (IIS)

    International journal of molecular sciencesFeb 28, 2022

More on Reactive oxygen species

Fat accumulation

downin worms1

1 study

  1. Pediococcus acidilactici decreases fat accumulation in worms.

    “The supplementation with pA1c reduced C. elegans fat accumulation in a nematode growth medium (NGM) and in a high-glucose (10 mM) NGM medium.”

    Model organismsin high-glucose (10 mM) NGM medium

    Pediococcus acidilactici CECT9879 (pA1c) Counteracts the Effect of a High-Glucose Exposure in C. elegans by Affecting the Insulin Signaling Pathway (IIS)

    International journal of molecular sciencesFeb 28, 2022

Lipid droplets

downin worms1

1 study

  1. Pediococcus acidilactici decreases lipid droplets in worms.

    “An immense reduction of the lipid droplets of C. elegans was identified through a fluorescent microscope.”

    Model organisms

    Anti-Obesity Efficacy of Pediococcus acidilactici MNL5 in Canorhabditis elegans Gut Model

    International journal of molecular sciencesJan 24, 2022

More on Lipid droplets

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