Lipid droplets
Biomarker1 paper1 finding
- Model organisms1
Interventions
1Silibinin
downin worms1Very low certainty
1 study
Silibinin
downin worms1Very low certainty
Silibinin decreases lipid droplets in worms.
Model organismsliver and EWATs
Silibinin Ameliorated Lipid Accumulation Through Insulin/IGF-1 signaling Pathway in HGI C. elegans · The Journal of nutritional biochemistry · 12 Sep 2026
Funding
National Institute on AgingUS$1.3m3 grants since 2023
National Institute on AgingUniversity of Maryland BaltimoreUS$546.2k2023–2028
Assessing the role of APOE in glial lipid droplet metabolism and function
National Institute on AgingUniv of North Carolina Chapel HillUS$571.7k2023–2028
Perilipin 5: Linking lipid droplets to nutrient sensing and healthy aging
National Institute on AgingVirginia Polytechnic Inst and St UnivUS$228.1k2024–2027
Latest
13A PPAR-gamma counterpart protects worm neurons by coordinating lipids and mitochondria
Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity…Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity declines with age.
4-Octyl itaconate restores parotid gland function in aging mice
The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.
Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes
Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with…Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.