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Pdgf-ab/bb

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Emory University and 1 more
  • Cells1

Outcomes

3

Expression of genes related to neurogenesis and response to mechanical stimulus

downin human cells1

1 study

  1. Pdgf-ab/bb decreases expression of genes related to neurogenesis and response to mechanical stimulus in human cells.

    “PDGF-AB/BB treatment resulted in downregulation of gene clusters related to neurogenesis and response to mechanical stimulus in AF cells”

    Cellsderived from degenerated intervertebral discsrecombinant humanannulus fibrosus cell5 days

    Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

    eLife2 Jun 2025Preprint

More on Expression of genes related to neurogenesis and response to mechanical stimulus

PDGFRA expression

upin human cells1

1 study

  1. Pdgf-ab/bb increases PDGFRA expression in human cells.

    “rhPDGF-AB/BB treatment increased PDGFRA expression”

    Cellsirradiation-induced senescencerecombinant humannucleus pulposus cell

    Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

    eLife2 Jun 2025Preprint

More on PDGFRA expression

Cellular senescence

downin human cells1

1 study

  1. Pdgf-ab/bb decreases cellular senescence in human cells.

    “rhPDGF-AB/BB treatment increased PDGFRA expression and mitigated the senescence progression through increased cell population in the S phase, reduced SA-β-Gal activity”

    Cellsirradiation-induced senescencerecombinant humannucleus pulposus cell

    Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

    eLife2 Jun 2025Preprint

More on Cellular senescence

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