1 paper3 findings
Plasma amyloid and tau biomarkers
no changein humans1
Particulate manganese is associated with plasma amyloid and tau biomarkers in humans (No significant associations).
“Neither PM10 nor Mn10 exposure showed significant associations with any biomarker.”
Humanscognitively unimpaired adultsMn10plasmaper interquartile-range increasen = 340
Air pollution particles link to distinct Alzheimer's markers
Environmental pollution (Barking, Essex : 1987)7 Oct 2026
pTau-181/Aβ42 ratio
upin humans1
Particulate manganese is associated with pTau-181/Aβ42 ratio in humans (β = 0.057, 95% CI 0.005 to 0.108).
“and the pTau-181/Aβ42 ratio (β = 0.057, 95% CI = 0.005, 0.108, p = 0.032).”
Humanscognitively unimpaired adults; single-pollutant modelMn2.5plasmaper interquartile-range increasen = 340
Air pollution particles link to distinct Alzheimer's markers
Environmental pollution (Barking, Essex : 1987)7 Oct 2026
pTau-181
upin humans1
Particulate manganese is associated with pTau-181 in humans (β = 0.387, 95% CI 0.084 to 0.691).
“Mn2.5 was positively associated with pTau-181 (β = 0.387, 95% CI = 0.084, 0.691, p = 0.013)”
Humanscognitively unimpaired adults; single-pollutant modelMn2.5plasmaper interquartile-range increasen = 340
Air pollution particles link to distinct Alzheimer's markers
Environmental pollution (Barking, Essex : 1987)7 Oct 2026
In 340 unimpaired adults, fine particles were linked to lower amyloid ratios while particulate manganese was linked to higher levels of tau.In 340 unimpaired adults, fine particles were linked to lower amyloid ratios while particulate manganese was linked to higher levels of tau.