Parabacteroides distasonis
Parabacteroides distasonis has been studied in 5 papers since 2022: none in people yet, 5 in animals; 2 in the past year. The research so far is in animals. The newest paper, Feb 3, 2026: “Gut Microbiota-Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol-Induced Cognitive and Social Dysfunction via CB1R-DRD2-RAP1 Signaling Axis”.
5 papers study it10 findingsUpdated
None of its findings points the other way.
- 3 independent labs in 4 countries
- Funders: National Institutes of Health and others
- Animals4
- Model organisms1
What did studies of Parabacteroides distasonis find?
10Studies of Parabacteroides distasonis measured 10 outcomes; the most studied are gut barrier integrity (1 study), climbing ability (1) and lifespan (1).
Gut barrier integrity
upin flies1
1 study
Gut barrier integrity
upin flies1
Parabacteroides distasonis improves gut barrier integrity in flies.
“Pd supplementation enhances gut barrier integrity in aged adults”
Model organisms
Aging and disease
Climbing ability
upin flies1
1 study
Climbing ability
upin flies1
Parabacteroides distasonis improves climbing ability in flies.
“promotes maintenance of climbing ability throughout adult life”
Model organisms
Aging and disease
Lifespan
upin flies1
1 study
Lifespan
upin flies1
Parabacteroides distasonis extends lifespan in flies.
“administration of Pd to adult Drosophila significantly increases median lifespan”
Model organisms
Aging and disease
Body-weight gain
downin mice1
1 study
Body-weight gain
downin mice1
Parabacteroides distasonis decreases body-weight gain in mice.
“Notably, Pd-supplemented mice challenged with a high-fat diet gain weight at a slower rate”
Animalshigh-fat diet
Aging and disease
Intestinal barrier function
upin mice1
1 study
Intestinal barrier function
upin mice1
Parabacteroides distasonis improves intestinal barrier function in mice.
“Additionally, FITC-dextran permeability assays indicate improved intestinal barrier function.”
Animalsintestine
Aging and disease
Colon shortening
downin mice1
1 study
Colon shortening
downin mice1
Parabacteroides distasonis decreases colon shortening in mice.
“Pd reduces colon shortening observed in aged control mice”
Animalscolon3 months
Aging and disease
Glucose
downin mice1
1 study
Glucose
downin mice1
Parabacteroides distasonis decreases glucose in mice.
“Pd-treated mice exhibit lower blood glucose levels and increased ketone body production.”
Animals3 months
Aging and disease
Muscle strength
upin mice1
1 study
Muscle strength
upin mice1
Parabacteroides distasonis improves muscle strength in mice.
“Pd supplementation enhances skeletal muscle strength in both 18- and 26-month-old mice.”
Animals3 months
Aging and disease
thermogenesis
upin mice1
1 study
thermogenesis
upin mice1
Parabacteroides distasonis increases thermogenesis in mice.
“ameliorated weight regain via increased thermogenesis”
Animalstreatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids
Nature communications
Weight regain
downin mice1
1 study
Weight regain
downin mice1
Parabacteroides distasonis decreases weight regain in mice.
“treatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids ameliorated weight regain”
Animalsrebound weight gain after calorie restriction
Nature communications