Panaxatriol

1. Panaxatriol decreases cellular senescence in human cells.

   “panaxatriol was found to exhibit senolytic activity on the etoposide-induced senescence of the IMR-90 cell line.”

   Cellsetoposide-induced senescenceIMR-90 cells

   Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs

   Molecules (Basel, Switzerland)·Jun 19, 2025

2. Panaxatriol inhibits cellular senescence in human cells.

   “Panaxatriol inhibited chondrocyte senescence through UFL1/forkhead box O1 (FOXO1)/P21 and UFL1/NF-κB/SASPs signaling pathways.”

   Cellscartilage explants and chondrocytes

   Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1

   Journal of advanced research·Oct 21, 2024

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1. Panaxatriol inhibits fibrosis.

   “It also could inhibit fibrocartilage formation during cartilage repair via the UFL1/FOXO1/Collagen 1 signaling pathway.”

   Animalscartilage

   Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1

   Journal of advanced research·Oct 21, 2024

1. Panaxatriol protects against osteoarthritis in mice.

   “Panaxatriol exerts anti-senescence effects and has the potential to delay OA progression and reduce cartilage repair fibrosis by targeting UFL1.”

   Animalssurgically induced OA mouse model

   Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1

   Journal of advanced research·Oct 21, 2024

More on Osteoarthritis