UFMylation
- 1 lab in 1 country
- Funders: Hebrew University of Jerusalem and 3 more
- Model organisms2
Effects
2Aggregation-prone protein toxicity
upin worms1
1 study
Aggregation-prone protein toxicity
upin worms1
UFMylation increases aggregation-prone protein toxicity in worms.
“lowering UFMylation extends lifespan and mitigates the toxicity of aggregation-prone proteins”
Model organismsshown by lowering UFMylation
Aging-associated modulation of UFMylation impairs proteostasis in C. elegans
Nature communications29 Apr 2026
Lifespan
downin worms1
1 study
Lifespan
downin worms1
UFMylation shortens lifespan in worms.
“We find that lowering UFMylation extends lifespan”
Model organismsshown by lowering UFMylation
Aging-associated modulation of UFMylation impairs proteostasis in C. elegans
Nature communications29 Apr 2026
Latest
2 in 12 monthsThe Journal of Biological Chemistry
Exploring the organismal role of UFMylation in development, stress resilience, and neurological function in Caenorhabditis elegans
Experiments in model organismsMechanisms
Nature Communications
Aging-associated modulation of UFMylation impairs proteostasis in C. elegans
Experiments in wormsProteostasis
iScience
UFMylation maintains YAP stability to promote vascular endothelial cell senescence
Experiments in animalsMechanisms
Cellular and Molecular Life Sciences
A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila
Experiments in fliesMechanisms