P5091

1. P5091 activates stem cell differentiation in mouse cells.

   “USP7 depletion and P5091 were shown to inhibit inflammation in senescent bone marrow-derived macrophages (BMDMs) and promote osteogenic differentiation in aged bone marrow mesenchymal stromal cells (BMSCs).”

   Cellsaged bone marrow mesenchymal stromal cells

   USP7 Inhibition Promotes Early Osseointegration in Senile Osteoporotic Mice

   Journal of dental research·Dec 9, 2024

More on Stem cell differentiation

1. P5091 inhibits inflammation in mouse cells.

   “USP7 depletion and P5091 were shown to inhibit inflammation in senescent bone marrow-derived macrophages (BMDMs)”

   Cellssenescent bone marrow-derived macrophages

   USP7 Inhibition Promotes Early Osseointegration in Senile Osteoporotic Mice

   Journal of dental research·Dec 9, 2024

More on Inflammation

1. P5091 improves early stage osseointegration in mice.

   “P5091 promoted the early stage of osseointegration, which may be related to macrophage efferocytosis around the implant.”

   Animalssenile osteoporotic mice

   USP7 Inhibition Promotes Early Osseointegration in Senile Osteoporotic Mice

   Journal of dental research·Dec 9, 2024

1. P5091 improves wound healing in rats.

   “Finally, P5091 can improve diabetic wound healing in rats.”

   Animalsdiabetic wound healing

   Targeting senescent HDF with the USP7 inhibitor P5091 to enhance DFU wound healing through the p53 pathway

   Biochemical and biophysical research communications·May 21, 2024

1. P5091 decreases cellular senescence in cells.

   “In addition, it induced apoptosis and selectively clears senescent cells through the p53 signaling pathway.”

   Cellsin senescent HDF

   Targeting senescent HDF with the USP7 inhibitor P5091 to enhance DFU wound healing through the p53 pathway

   Biochemical and biophysical research communications·May 21, 2024

More on Cellular senescence

1. P5091 decreases senescence-associated secretory phenotype (SASP) in cells.

   “USP7 inhibitors (P5091) could reduce the release of SASP factors, activate the production of ROS, and reduce MMP.”

   Cellsin high-glucose senescent HDF

   Targeting senescent HDF with the USP7 inhibitor P5091 to enhance DFU wound healing through the p53 pathway

   Biochemical and biophysical research communications·May 21, 2024

More on Senescence-associated secretory phenotype (SASP)