Olea europaea leaf

1. Olea europaea leaf has no effect on MMP2 in humans.

   “Collagen, hydroxyproline, MMP-2, and glucose remained unaffected.”

   Human trialhealthy250 mg daily12 weeksfemalesn = 65

   Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled trial with exploratory skin outcomes

   Frontiers in nutrition·18 Nov 2025

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1. Olea europaea leaf decreases pentosidine in humans (-0.75 [-1.40; -0.11]).

   “Pentosidine significantly decreased in the OLE group compared to placebo [-0.75 [-1.40; -0.11], p = 0.022], but also not after correction (p adj = 0.088).”

   Human trialhealthy250 mg daily12 weeksfemalesn = 65

   Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled trial with exploratory skin outcomes

   Frontiers in nutrition·18 Nov 2025

More on Pentosidine

1. Olea europaea leaf decreases pore number in humans (-7.86 [0.64; 15.07]).

   “At week 12, the OLE group had a significantly lower pore number compared to placebo [-7.86, [0.64; 15.07], p = 0.034].”

   Human trialhealthyskin250 mg daily12 weeksfemalesn = 26

   Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled trial with exploratory skin outcomes

   Frontiers in nutrition·18 Nov 2025

More on Pore number