Obesity

5 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: European Commission and 4 more

Humans5

Outcomes

Cognitive decline

downin humans1

1 study

Obesity decreases cognitive decline in humans (β = 0.86, p < 0.05).
“Specifically, obese (β = 0.86, p < 0.05) and overweight (β = 0.95, p <0.05) participants showed a slower rate of decline in MoCA over five visits”
Humans5 annual visitsn = 526
Rethinking the Obesity Paradox: BMI and Longitudinal Cognitive Decline in Older Adults
AAIC 2025 abstract23 Dec 2025

Tau burden

no changein humans1

1 study

Obesity has no effect on tau burden in humans.
“No significant between‐group differences in tau burden were observed in the ROIs.”
Humansbrainn = 80
Brain Structural Changes and Amyloid Burden Linked to Midlife Obesity and Insulin Resistance: Implications for Alzheimer's Disease Risk
AAIC 2025 abstract23 Dec 2025

Associations

High-sensitivity cardiac troponin I

upin humans1

1 study

Obesity is associated with high-sensitivity cardiac troponin I in humans (+11.00% (95% CI, 4.62-17.37)).
“Among men, ever having been obese was associated with 11.00% (95% CI, 4.62-17.37) higher hs-cTnI in the fully adjusted model”
Humansamong men, fully adjusted modelmales
More years of obesity linked to heart stress and injury markers
medRxiv11 Oct 2026Preprint

More on High-sensitivity cardiac troponin I

Endometrioid carcinoma

upin silico1

1 study

Obesity raises the risk of endometrioid carcinoma in silico (+27% risk (95% CI 1.19-1.36)).
“Class I obesity (BMI 30-34.9 kg/m 2 ) was associated with a 27% heightened risk of endometrioid carcinoma (95% CI 1.19-1.36; P < 0.001)”
In silicoClass I obesity (BMI 30-34.9 kg/m2)
Causal impact of obesity class stratification and endometrial cancer subtypes: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis
International journal of surgery (London, England)1 Jul 2025