Overweight

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 3 countries

Funders: National Institute on Aging and others

Humans3

Outcomes

CMRO2

downin humans1

1 study

Overweight decreases CMRO2 in humans (β = -1.12 μmol/100 g/min, 95%CI = (-1.96, -0.28)).
“Adiposity was associated with lower CMRO2: with overweight (β = -1.12 μmol/100 g/min, 95%CI = (-1.96, -0.28))”
Humansbrainn = 303
Life-course body shape trajectories and cerebral oxygen metabolism in community-dwelling older adults
GeroScience12 Jan 2026

Associations

Mortality

downin humans1HR 0.79

1 study

Overweight lowers the risk of mortality in humans (HR 0.79, 95% CI 0.64-0.96).
“Overweight participants with FI scores >0.3 were at lower risk for mortality compared to normal BMI [NHANES (0.79, 0.64-0.96); SHARE (0.71, 0.63-0.80)].”
HumansFI scores >0.3 (moderately/severely frail) in NHANES
Relationship of body mass index with frailty and all-cause mortality among middle-aged and older adults
BMC medicine24 Oct 2022

Funding

9 grants since 2023

National Institute on AgingUS$2.2mNational Institute of Diabetes and Digestive and Kidney DiseasesUS$1.5mNational Heart, Lung, and Blood InstituteUS$758.5k