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O-GlcNAc transferase inhibition

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Institute for Basic Science and 5 more
  • Animals1

Outcomes

1

Osteoarthritis

downin mice1

1 study

  1. O-GlcNAc transferase inhibition decreases osteoarthritis in mice.

    “inhibiting O-GlcNAc transferase mitigates OA by decreasing GATA4 levels”

    Animalspost-traumatic osteoarthritis

    Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation

    Nature communications4 Feb 2025

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